N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic
regulation that is commonly observed in both prokaryotic and eukaryotic organisms. Their …

The potential antimicrobial activity and low propensity to induce the development of bacterial
resistance have rendered antimicrobial peptides (AMPs) as novel and ideal candidate …

Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional chemical
modifications. Approximately 100 different modifications have been identified in tRNAs, and …

Acinetobacter baumannii causes life-threatening infections that are becoming difficult to treat
due to increasing rates of multi-drug resistance (MDR) among clinical isolates. This has led …

Despite being a major human pathogen, limited studies have reported RNA modifications in
Acinetobacter baumannii. These post-transcriptional modifications play crucial regulatory …

Transfer RNAs (tRNAs) are the most highly modified cellular RNAs, both with respect to the
proportion of nucleotides that are modified within the tRNA sequence and with respect to the …

Acinetobacter baumannii can cause prolonged infections that disproportionately affect
immunocompromised populations. Our understanding of A. baumannii respiratory …

Antibiotic resistance is the leading cause of death globally, with a higher possibility of the
emergence of highly resistant pathogens, leading to epidemics. Several antibiotic resistance …

This dissertation explores the intersection of infection, inflammation, and bacterial virulence
mechanisms using innovative models and approaches to address critical challenges in …