Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from
2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes …

Protein glycosylation is a ubiquitous post‐translational modification that is involved in the
regulation of many aspects of protein function. In order to uncover the biological roles of this …

Abstract O‐linked N‐acetylglucosamine (O‐GlcNAcylation) is a ubiquitous post‐translational
modification of proteins that is essential for cell function. Perturbation of O‐GlcNAcylation …

Fucosylation is a glycan modification critically involved in cancer and inflammation. Although
potent fucosylation inhibitors are useful for basic and clinical research, only a few inhibitors …

Metabolic chemical reporters of glycosylation in combination with bioorthogonal reactions
have been known for two decades and have been used by many different research …

Highlights•Posttranslational modifications (PTMs) increase the chemical diversity of
proteins.•The unbiased identification of some PTM substrates remains challenging.•Several …

Glycans can be directly labeled using unnatural monosaccharide analogs, termed metabolic
chemical reporters (MCRs). These compounds enable the secondary visualization and …

Protein prenylation is a post-translational modification that is responsible for membrane
association and protein–protein interactions. The oncogenic protein Ras, which is …

The recent advancement in the human glycome and progress in the development of an
inclusive network of glycosylation pathways allow the incorporation of suitable machinery for …