NMR is very well suited to the study of especially weak protein− protein interactions, as no
crystallization is required. The available NMR methods to this end are reviewed and …

Considerable advances have been made in our knowledge of the molecular structure of cell
adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein …

Protein stability and function relies on residues being in their appropriate ionization states at
physiological pH. In situ residue pK as also provides a sensitive measure of the local protein …

Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at
intermediate stages of folding, assembly, and translocation across membranes. Binding of …

γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and
proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident …

The oncoprotein MDM2 inhibits the tumor suppressor protein p53 by binding to the p53
transactivation domain. The p53 gene is inactivated in many human tumors either by …

The nucleocapsid of measles virus is the template for viral RNA synthesis and is generated
through packaging of the genomic RNA by the nucleocapsid protein (N). The viral …

Rapid progress has recently been made in characterising the structures of leukocyte cell‐
surface molecules. Detailed analyses of the structure and interactions of CD2 were the first …

The intrinsically disordered protein p15PAF regulates DNA replication and repair by binding
to the proliferating cell nuclear antigen (PCNA) sliding clamp. We present the structure of the …