Osteoarthritis (OA) is a degenerative joint condition characterized by painful cartilage
lesions that impair joint mobility. Current treatments such as lavage, microfracture, and …

Back pain is one of the leading causes of disability worldwide and is frequently caused by
degeneration of the intervertebral discs. The discs' development, homeostasis, and …

Multi-material 3D printing technologies that resolve features at different lengths down to the
microscale open new avenues for regenerative medicine, particularly in the engineering of …

Regenerative medicine strategies for restoring articular cartilage face significant challenges
to recreate the complex and dynamic biochemical and biomechanical functions of native …

Chondrogenically primed bone marrow-derived mesenchymal stem cells (MSCs) have been
shown to become hypertrophic and undergo endochondral ossification when implanted in …

Tissue engineering strategies for repairing and regenerating articular cartilage face critical
challenges to recapitulate the dynamic and complex biochemical microenvironment of …

Patients with bone and cartilage defects due to infection, tumors, and trauma are quite
common. Repairing bone and cartilage defects is thus a major problem for clinicians …

Recapitulation of the articular cartilage microenvironment for regenerative medicine
applications faces significant challenges due to the complex and dynamic biochemical and …

In the past few years, great progress has been made to validate tissue engineering
strategies in preclinical studies and clinical trials on the regeneration of osteochondral …

Introduction: A major hurdle in treating osteochondral (OC) defects is the different healing
abilities of two types of tissues involved–articular cartilage and subchondral bone …