5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or
neurotransmitter of several nervous system functions. Its actions are complex, and depend …

Dravet syndrome (DS) is a genetic encephalopathy that is characterized by severe seizures
and prominent co-morbidities (eg, physical, intellectual disabilities). More than 85% of the …

The use of dopamine receptor blockers for chronic singultus treatment is based—at least
partially—on circular thinking: chlorpromazine is FDA-approved for hiccups, chlorpromazine …

This study aimed to investigate whether the 5-HT 2 receptor blockade alters the 5-HT effect
on vascular sympathetic neurotransmission and platelet activation in type 1 diabetes. 28-day …

Background and Purpose In male rats, the serotonergic system modulates sympathetic
outflow at vascular levels, causing sympatho‐inhibition and sympatho‐excitation, mainly via …

Aims This study investigated whether fluoxetine treatment changes the 5-HT regulation on
vascular sympathetic neurotransmission in type 1 diabetes. Main methods Four-week …

Renal vasculature, which is highly innervated by sympathetic fibers, contributes to
cardiovascular homeostasis. This renal sympathetic outflow is inhibited by 5-HT in …

Given the interconnection between depressive and cardiovascular disorders, we
investigated whether antidepressant treatment (fluoxetine) modifies the serotonergic …

Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin
regulation on renal sympathetic outflow has not yet been elucidated. This study investigated …

Serotonin (5-hydroxytryptamine; 5-HT) inhibits the rat cardioaccelerator sympathetic outflow
by 5-HT1B/1D/5 receptors. Because chronic blockade of sympatho-excitatory 5-HT2 …