In this concept article, we outline a variety of new approaches that have been conceived to
address some of the remaining challenges for developing improved methods of …

Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

Background A significant proportion of donation after circulatory death (DCD) kidneys are
declined for transplantation because of concerns over their quality. Ex vivo normothermic …

Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Introduction Ex vivo normothermic perfusion (EVNP) is a novel technique that reconditions
the kidney and restores renal function prior to transplantation. Phase I data from a series of …

Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

Transportable normothermic kidney perfusion for 24 hours or longer could enable viability
assessment of marginal grafts, increased organ use, and improved transplant logistics …

Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

The increased demand for organs has led to the increased usage of “higher risk” kidney and
liver grafts. These grafts from donation after circulatory death or expanded criteria donors …