Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive,
complex, and heterogeneous malignancies. The standard of care treatments for HNC …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed
cancer worldwide. Despite advances in the treatment management, locally advanced …

Despite major progress in elucidating the pathobiology of head and neck squamous cell
carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably …

Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in
tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have …

Abstract Interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in
several regulatory mechanisms of cancer. Moreover, experimental and clinical studies have …

It was recognized over 30 years ago that the polyfunctional cytokine interleukin-6 (IL-6) was
an almost invariant presence at the host-tumor interface. The IL-6 in the tumor …

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It
was previously reported to play a distinct role in inflammation, autoimmune and psychiatric …

Abstract Cytokines, particularly IL-6, play a crucial role in modulating immune responses in
the central nervous system (CNS). Elevated IL-6 levels have been observed in …