Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Pregnant women are especially susceptible to malaria infection. Without existing immunity,
severe malaria can develop requiring emergency treatment, and pregnancy loss is common …

Background: Antiretroviral drug discovery and formulation design will facilitate viral
clearance in infectious reservoirs. Although progress has been realized for selected …

Background Antiretroviral treatment is highly effective in enhancing HIV-positive patients'
survival and quality of life. Despite an increased tolerability in recent years, a substantial …

Purpose CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase
inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) …

Objectives Dolutegravir has replaced efavirenz as first-line treatment in universal HIV
guidelines. We sought to ascertain the contributory effect of SNPs in four key genes linked to …

Background: Pharmacogenetic studies have shown that slow and intermediate metabolizers
of efavirenz (EFV) gained less weight compared with extensive metabolizers. It is …

We demonstrate the suitability of a fast, green, easy-to-perform, and modified sample
extraction procedure, ie, dispersive liquid–liquid microextraction (DLLME) for the …

Introduction: Variations in the human genome sequence sometimes play an important role in
pharmacokinetics and/or pharmacodynamics. Previous studies have demonstrated a high …

The new multicomponent reaction has been found: the pyridine or triethylamine catalyzed
multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1, 1, 3-tricarbonitrile …