Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …

Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …

Recent studies have demonstrated that RNAi is a promising approach for treating autosomal
dominant disorders. However, discrimination between wild-type and mutant transcripts is …

Neurodegenerative disorders involve death of cell bodies, axons, dendrites and synapses,
but it is surprisingly difficult to determine the spatiotemporal sequence of events and the …

The adenosine monophosphate activated kinase protein (AMPK) is an evolutionary-
conserved protein important for cell survival and organismal longevity through the …

The aim of this study is to review the methods being used for image analysis of microscopic
views of immunohistochemically stained specimen in medical research. The solutions …

Human CA150, a transcriptional activator, binds to and is co-deposited with huntingtin
during Huntington's disease. The second WW domain of CA150 is a three-stranded β-sheet …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of glutamine repeats in the huntingtin (htt) protein. Abnormal protein folding and …

Machado–Joseph disease or spinocerebellar ataxia type 3 (MJD/SCA3) is a fatal, autosomal
dominant disorder caused by a cytosine-adenine-guanine expansion in the coding region of …