Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

In a significant fraction of breast cancer patients, distant metastases emerge after years or
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and …

Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular
processes; however, their unique contributions are not well understood. We generated …

Besides its essential and well established role as a component of the cytoskeleton, actin is
also present in the cell nucleus, where it has been linked to many processes that control …

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular
responses that control cell fate changes. Mechanical forces also physically distort …

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as
it represents a major obstacle to effective cancer treatment. Since tumor cells are highly …

There is a considerable resurgence of interest in the role of aerobic glycolysis in cancer;
however, increased glycolysis is frequently viewed as a consequence of oncogenic events …

While actin was discovered in the nucleus over 50 years ago, research lagged for decades
due to strong skepticism. The revitalization of research into nuclear actin occurred after it …