Iron is an essential metal for the body, while excess iron accumulation causes organ
dysfunction through the production of reactive oxygen species. There is a sophisticated …

Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …

Abstract" Serum ferritin" presents a paradox, as the iron storage protein ferritin is not
synthesised in serum yet is to be found there. Serum ferritin is also a well known …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

The cardiomyopathies are heart muscle diseases of pri-mary or secondary origin. Primary
cardiomyopathies are often of unknown cause, hence their treatment is limited to general …

Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell (HSC) disorders
predominating in the elderly, characterised by ineffective haematopoiesis leading to blood …

Labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is
both redox-active and chelatable, capable of permeating into organs and inducing tissue …

Cardiac T2*(magnetic resonance imaging relaxation parameter) is abnormally low in
approximately 40% of adults with thalassemia major (TM), suggesting myocardial iron …

In the past seven years numerous genes that influence iron homeostasis have been
discovered. Dr. Beutler provides a brief overview of these genes, genes that encode HFE …

Background There is a need to standardise non-invasive measurements of liver iron
concentrations (LIC) so clear inferences can be drawn about body iron levels that are …