Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …

Recent reports in oncological and non-oncological experimental setups provide strong
evidence that senescent cells are under the surveillance of CD8 T cell-mediated adaptive …

Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the
tumor microenvironment, favoring immunosuppression and tumor growth. We discovered …

The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …

Cancer progression is continuously controlled by the immune system which can identify and
destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

Evidence shows that stress can promote the occurrence and development of tumors. In
recent years, many studies have shown that stress-related hormones or peripheral …

Cellular senescence is a biological aging hallmark that plays a key role in the development
of neurodegenerative diseases. Clinical trials are currently underway to evaluate the …

Older patients with cancer, particularly those over 75 years of age, often experience poorer
clinical outcomes compared to younger patients. This can be attributed to age-related …

Senescence occurs in response to various stimuli. Senescence has attracted attention
because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also …