The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured
signaling pathways that recognize and repair DNA damage, and the immune response to …

Autoantibodies reactive against host DNA are detectable in the circulation of most people
with systemic lupus erythematosus (SLE). The long-held view that antibodies cannot …

Introduction Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease
characterized by various systemic symptoms and multiple organ damage. We clarify …

Background Excessive autoantibody production characterizing systemic lupus
erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to …

Systemic Lupus Erythematosus (SLE) is one of the most relevant world-wide autoimmune
disorders. The formation of autoantibodies and the deposition of antibody-containing …

Lupus is a systemic autoimmune disease characterized by the production of autoreactive
antibodies against nuclear antigens. Women are disproportionately affected by lupus, and …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure
that affects at least five million people worldwide. Monozygotic twin concordance and …

Background and objectives: Exposure to ionizing radiation (IR) has increased immensely
over the past years, owing to diagnostic and therapeutic reasons. However, certain …

Objective DNA double-strand breaks (DSBs) lead to mutations, genomic instability and
apoptotic death, whereas accumulation of apoptotic cells results in excessive autoantigen …

The lifespan of humans has increased drastically over the last decades; considerable effort
has been applied to delineate the mechanisms behind aging in order to find strategies for …