Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

By its action on rhodopsin, light triggers the well-known visual transduction cascade, but can
also induce cell damage and death through phototoxic mechanisms–a comprehensive …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

Comparative analysis of the transcriptional profiles of approximately 6000 genes in the
retinas of wild-type mice with those carrying a targeted disruption of the rhodopsin gene was …

Lipid metabolism-related gene mutations can cause retinitis pigmentosa, a currently
untreatable blinding disease resulting from progressive neurodegeneration of the retina …

purpose. To test for apoptotic photoreceptor cell death and caspase activation as a function
of time after induction of an experimental retinal detachment. methods. Retinal detachments …

The long-term outcome of neuroprotection as a therapeutic strategy for preventing cell death
in neurodegenerative disorders remains unknown, primarily due to slow disease …

The tightly structured neural retina has a unique vascular network comprised of three
interconnected plexuses in the inner retina (and choroid for outer retina), which provide …

Background Bone spicule pigments (BSP) are a hallmark of retinitis pigmentosa (RP). In this
study, we examined the process of BSP formation in the rhodopsin knockout (rho-/-) mouse …

The rhodopsin gene (RHO) encodes a highly expressed G protein-coupled receptor that is
central to visual transduction in rod photoreceptors. A suite of recombinant 2/5 adeno …