Biochemistry of peroxynitrite and protein tyrosine nitration

G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Peroxynitrite, a stealthy biological oxidant

R Radi - Journal of Biological Chemistry, 2013 - ASBMB
Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …

Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects

R Radi - Accounts of chemical research, 2013 - ACS Publications
In proteins, the nitration of tyrosine residues to 3-nitro-tyrosine represents an oxidative post-
translational modification that disrupts nitric oxide (• NO) signaling and skews metabolism …

[HTML][HTML] Interplay between oxidant species and energy metabolism

C Quijano, M Trujillo, L Castro, A Trostchansky - Redox biology, 2016 - Elsevier
It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

[HTML][HTML] Manganese superoxide dismutase, MnSOD and its mimics

S Miriyala, I Spasojevic, A Tovmasyan… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

[图书][B] Plant roots: the hidden half

A Eshel, T Beeckman - 2013 - books.google.com
The decade since the publication of the third edition of this volume has been an era of great
progress in biology in general and the plant sciences in particular. This is especially true …

Anti‐cancer therapies of 21st century: novel approach to treat human cancers using cold atmospheric plasma

EA Ratovitski, X Cheng, D Yan… - Plasma Processes …, 2014 - Wiley Online Library
Cold atmospheric plasma (CAP) has just recently been showing promising anti‐cancer
activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading …

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

AT Akhmedov, V Rybin, J Marín-García - Heart failure reviews, 2015 - Springer
Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function

N Campolo, FM Issoglio, DA Estrin… - Essays in …, 2020 - portlandpress.com
Oxidative post-translational modification of proteins by molecular oxygen (O2)-and nitric
oxide (• NO)-derived reactive species is a usual process that occurs in mammalian tissues …

Trypanosoma cruzi Antioxidant Enzymes As Virulence Factors in Chagas Disease

L Piacenza, G Peluffo, MN Alvarez… - Antioxidants & Redox …, 2013 - liebertpub.com
Significance: Chagas disease (CD) affects several million people in Latin America and is
spreading beyond its classical boundaries due to the migration of infected host and insect …