Neurostimulation is now an established therapy for the treatment of movement disorders,
pain, and epilepsy. While most neurostimulation systems available today provide stimulation …

Background A significant proportion of patients with Tourette syndrome (TS) continue to
experience symptoms across adulthood that in severe cases fail to respond to standard …

Deep brain stimulation (DBS) may improve disabling tics in severely affected medication
and behaviorally resistant Tourette syndrome (TS). Here we review all reported cases of TS …

Major depressive disorder (MDD) is a widespread, severe, debilitating disorder that
markedly diminishes quality of life. Medication is commonly effective, but 20–30% of patients …

OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The
development of neuromodulation therapies depends on a better understanding of these …

Of all the truncothalamic nuclei, the centromedian-parafascicular nuclei complex (CM-Pf) is
the largest and is considered the prototypic thalamic projection system. Located among the …

Invasive and noninvasive neurostimulation therapies for obsessive-compulsive and related
disorders (OCRD) were systematically reviewed with the aim of assessing clinical …

Background Deep brain stimulation (DBS) has been proposed as a treatment option for
severe Tourette's syndrome on the basis of findings from open-label series and small double …

Fossil records showing trephination in the Stone Age provide evidence that humans have
sought to influence the mind through physical means since before the historical record …

Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened
patients with specific treatment-resistant neuropsychiatric diseases. Some neuropsychiatric …