Recurrent pregnancy loss

E Dimitriadis, E Menkhorst, S Saito… - Nature reviews disease …, 2020 - nature.com
Recurrent pregnancy loss is a distressing pregnancy disorder experienced by~ 2.5% of
women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more …

[HTML][HTML] Maternal selection of human embryos in early gestation: insights from recurrent miscarriage

JJ Brosens, PR Bennett, VM Abrahams… - Seminars in cell & …, 2022 - Elsevier
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally
diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate …

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

TM Rawlings, K Makwana, DM Taylor, MA Molè… - Elife, 2021 - elifesciences.org
Decidual remodelling of midluteal endometrium leads to a short implantation window after
which the uterine mucosa either breaks down or is transformed into a robust matrix that …

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

ES Lucas, P Vrljicak, J Muter… - Communications …, 2020 - nature.com
During the implantation window, the endometrium becomes poised to transition to a
pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC) …

[HTML][HTML] Unveiling uterine aging: much more to learn

Y Wu, M Li, J Zhang, S Wang - Ageing Research Reviews, 2023 - Elsevier
Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …

[HTML][HTML] Research progress of stem cell therapy for endometrial injury

J Cen, Y Zhang, Y Bai, S Ma, C Zhang, L Jin, S Duan… - Materials Today Bio, 2022 - Elsevier
Endometrial damage is an important factor leading to infertility and traditional conventional
treatments have limited efficacy. As an emerging technology in recent years, stem cell …

Miscarriage syndrome: linking early pregnancy loss to obstetric and age-related disorders

P Bortoletto, ES Lucas, P Melo, ID Gallos, AJ Devall… - …, 2022 - thelancet.com
Upon embryo implantation, the uterine mucosa-the endometrium-transforms into a robust
decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition …

[HTML][HTML] Endometrial stem cells: Orchestrating dynamic regeneration of Endometrium and their implications in Diverse Endometrial disorders

IS Hong - International Journal of Biological Sciences, 2024 - ncbi.nlm.nih.gov
The human endometrium, a vital component of the uterus, undergoes dynamic changes
during the menstrual cycle to create a receptive environment for embryo implantation. Its …

Adult stem cells in endometrial regeneration: Molecular insights and clinical applications

Q Lv, L Wang, X Luo, X Chen - Molecular Reproduction and …, 2021 - Wiley Online Library
Endometrial damage is an important cause of female reproductive problems, manifested as
menstrual abnormalities, infertility, recurrent pregnancy loss, and other complications. These …

Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium

M Diniz-da-Costa, CS Kong, KJ Fishwick… - Stem Cells, 2021 - academic.oup.com
Pregnancy depends on the wholesale transformation of the endometrium, a process driven
by differentiation of endometrial stromal cells (EnSC) into specialist decidual cells. Upon …