The hnRNP family: insights into their role in health and disease

T Geuens, D Bouhy, V Timmerman - Human genetics, 2016 - Springer
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …

Defining the RGG/RG motif

P Thandapani, TR O'Connor, TL Bailey, S Richard - Molecular cell, 2013 - cell.com
Motifs rich in arginines and glycines were recognized several decades ago to play functional
roles and were termed glycine-arginine-rich (GAR) domains and/or RGG boxes. We review …

The RGG motif proteins: Interactions, functions, and regulations

MN Chowdhury, H Jin - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

HIV-1: to splice or not to splice, that is the question

A Emery, R Swanstrom - Viruses, 2021 - mdpi.com
The transcription of the HIV-1 provirus results in only one type of transcript—full length
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …

A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing

X Tang, Z Deng, P Ding, W Qiang, Y Lu, S Gao… - Journal of Experimental …, 2022 - Springer
Backgroud Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone
marrow (BM), while immunoglobulin D type of MM (IgD MM) is a very rare but most severe …

Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle

J Wang, D Sun, M Wang, A Cheng, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …

Making the mark: the role of adenosine modifications in the life cycle of RNA viruses

SR Gonzales-van Horn, P Sarnow - Cell host & microbe, 2017 - cell.com
Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA
modifications in modulating life cycles of RNA viruses. Despite the observation of a handful …

Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs

Y Fuentes, V Olguín, B López-Ulloa… - Nucleic Acids …, 2024 - academic.oup.com
Translation initiation of the human immunodeficiency virus-type 1 (HIV-1) genomic mRNA
(vRNA) is cap-dependent or mediated by an internal ribosome entry site (IRES). The HIV-1 …

Methylarginines within the RGG-motif region of hnRNP A1 affect its IRES trans-acting factor activity and are required for hnRNP A1 stress granule localization and …

ML Wall, SM Lewis - Journal of molecular biology, 2017 - Elsevier
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a stress granule-associated
RNA-binding protein that plays a role in apoptosis and cellular stress recovery. HnRNP A1 is …

Identification of host proteins differentially associated with HIV-1 RNA splice variants

R Knoener, E Evans III, JT Becker, M Scalf, B Benner… - Elife, 2021 - elifesciences.org
HIV-1 generates unspliced (US), partially spliced (PS), and completely spliced (CS) classes
of RNAs, each playing distinct roles in viral replication. Elucidating their host protein …