GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants
Nuclear localization signal (NLS) of HIV-1 integrase (IN) is implicated in nuclear import of
HIV-1 preintegration complex (PIC). Here, we established a multiclass drug-resistant HIV-1 …
HIV-1 preintegration complex (PIC). Here, we established a multiclass drug-resistant HIV-1 …
[HTML][HTML] Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV
N Higashi-Kuwata, S Hayashi, H Kumamoto… - Journal of …, 2021 - Elsevier
Background & Aims While certain nucleos (t) ide reverse transcriptase inhibitors (NRTIs) are
efficacious in treating HBV infection, their effects are yet to be optimized and the emergence …
efficacious in treating HBV infection, their effects are yet to be optimized and the emergence …
FMO-guided design of darunavir analogs as HIV-1 protease inhibitors
H Chuntakaruk, K Hengphasatporn, Y Shigeta… - Scientific Reports, 2024 - nature.com
The prevalence of HIV-1 infection continues to pose a significant global public health issue,
highlighting the need for antiretroviral drugs that target viral proteins to reduce viral …
highlighting the need for antiretroviral drugs that target viral proteins to reduce viral …
Self-assembled enzymatic nanowires with a “dry and wet” interface improve the catalytic performance of januvia transaminase in organic solvents
The use of organic solvents in enzymatic reactions is advantageous for industrial
bioprocesses. However, enzymes tend to denature in organic solvents. To solve this …
bioprocesses. However, enzymes tend to denature in organic solvents. To solve this …
HIV-1 protease inhibitors and mechanisms of HIV-1's resistance
D Das - Global Health & Medicine, 2024 - jstage.jst.go.jp
Current anti-HIV drugs have significantly improved the prognosis of HIV infected patients so
much so that it is now considered a chronic disease, and adherence to medications keeps …
much so that it is now considered a chronic disease, and adherence to medications keeps …
[HTML][HTML] A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs
M Shimura, N Higashi-Kuwata, A Fujiwara… - Antiviral Research, 2024 - Elsevier
HIV-associated lipodystrophy has been reported in people taking anti-retroviral therapy
(ART). Lipodystrophy can cause cardiovascular diseases, affecting the quality of life of HIV …
(ART). Lipodystrophy can cause cardiovascular diseases, affecting the quality of life of HIV …
7-Deaza-7-fluoro modification confers on 4′-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety
S Hayashi, N Higashi-Kuwata, D Das, K Tomaya… - Antiviral research, 2020 - Elsevier
We designed, synthesized and identified a novel nucleoside derivative, 4′-C-cyano-7-
deaza-7-fluoro-2′-deoxyadenosine (CdFA), which exerts potent anti-HBV activity (IC 50 …
deaza-7-fluoro-2′-deoxyadenosine (CdFA), which exerts potent anti-HBV activity (IC 50 …