We review computational predictions of expression from the promoter architecture–the set of
transcription factors that can bind the proximal promoter. We focus on spatial expression …

Cooperativity between transcription factors is important to regulate target gene expression.
In particular, the binding grammar of TFs in relation to each other, as well as in the context of …

Transcription regulation in metazoa is controlled by the binding events of transcription
factors (TFs) or regulatory proteins on specific modular DNA regulatory sequences called cis …

The concept of cis-regulatory modules located in gene promoters represents today's vision
of the organization of gene transcriptional regulation. Such modules are a combination of …

Abstract Background Transcription factors (TFs) are important regulatory proteins that
govern transcriptional regulation. Today, it is known that in higher organisms different TFs …

Background Current technologies for understanding the transcriptional reprogramming in
cells include the transcription factor (TF) chromatin immunoprecipitation (ChIP) experiments …

Today, it is well-known that in eukaryotic cells the complex interplay of transcription factors
(TFs) bound to the DNA of promoters and enhancers is the basis for precise and specific …

The discovery of cis-regulatory modules (CRMs) is a challenging problem in computational
biology. Limited by the difficulty of using an HMM to model dependent features in …

The discovery of cis‐regulatory modules (CRMs) is the key to understanding mechanisms of
transcription regulation. Since CRMs have specific regulatory structures that are the basis for …

顺式调控模块(Cis-regulatory module, CRM) 在真核生物基因的转录调控中起着重要作用,
识别顺式调控模块是当前计算生物学的一个重要课题. 虽然当前有许多计算方法用于识别顺式 …