M Bentsen, V Heger, H Schultheis, C Kuenne… - Computational and …, 2022 - Elsevier
Cooperativity between transcription factors is important to regulate target gene expression. In particular, the binding grammar of TFs in relation to each other, as well as in the context of …
TH Yang, YC Yang, KC Tu - Computational and Structural Biotechnology …, 2022 - Elsevier
Transcription regulation in metazoa is controlled by the binding events of transcription factors (TFs) or regulatory proteins on specific modular DNA regulatory sequences called cis …
IV Deyneko - International Journal of Molecular Sciences, 2024 - mdpi.com
The concept of cis-regulatory modules located in gene promoters represents today's vision of the organization of gene transcriptional regulation. Such modules are a combination of …
C Meckbach, R Tacke, X Hua, S Waack… - BMC …, 2015 - Springer
Abstract Background Transcription factors (TFs) are important regulatory proteins that govern transcriptional regulation. Today, it is known that in higher organisms different TFs …
Background Current technologies for understanding the transcriptional reprogramming in cells include the transcription factor (TF) chromatin immunoprecipitation (ChIP) experiments …
C Meckbach, E Wingender, M Gültas - Frontiers in genetics, 2018 - frontiersin.org
Today, it is well-known that in eukaryotic cells the complex interplay of transcription factors (TFs) bound to the DNA of promoters and enhancers is the basis for precise and specific …
H Guo, H Huo, Q Yu - Plos one, 2016 - journals.plos.org
The discovery of cis-regulatory modules (CRMs) is a challenging problem in computational biology. Limited by the difficulty of using an HMM to model dependent features in …
H Guo, H Huo - BioMed Research International, 2017 - Wiley Online Library
The discovery of cis‐regulatory modules (CRMs) is the key to understanding mechanisms of transcription regulation. Since CRMs have specific regulatory structures that are the basis for …