1. INTRODUCTION Despite being largely absent from natural products and biological
processes, fluorine plays a conspicuous and increasingly important role within …

Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Fluorination reactions of medicinal and biologically-active compounds will be discussed.
Late stage fluorination strategies of medicinal targets have recently attracted considerable …

Conspectus Modern density functional theory and powerful contemporary computers have
made it possible to explore complex reactions of value in organic synthesis. We describe …

The cinchona alkaloid-derived urea-catalyzed asymmetric conjugate addition of aromatic
thiols to cycloalkenones was studied using density functional theory (DFT). Deprotonation of …

Accomplishing high diastereo-and enantioselectivities simultaneously is a persistent
challenge in asymmetric catalysis. The use of two chiral catalysts in one-pot conditions might …

The organic chemist's toolbox is vast, with technologies to accelerate the synthesis of novel
chemical matter. The field of asymmetric catalysis is one approach to accessing new areas …

A Cu‐catalyzed asymmetric detrifluoroacetylative aldol addition reaction of 2‐fluoro‐1, 3‐
diketones/hydrates to aldehydes in the presence of base and chiral bidentate ligand was …

We report density functional theory calculations that examine the mechanism and origins of
stereoselectivity of Soós' landmark discovery from 2005 that cinchona thioureas catalyze the …

Wynberg's report from 1977 that natural cinchona alkaloids catalyze the asymmetric
conjugate addition of aromatic thiols to cycloalkenones is a landmark discovery in hydrogen …