Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Crohn's disease and ulcerative colitis are two idiopathic inflammatory bowel disorders. In
this paper we discuss the current diagnostic approach, their pathology, natural course, and …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which imbalances in pro-and
anti-inflammatory cytokines promote the induction of autoimmunity, inflammation and joint …

Molecular danger signals attract neutrophilic granulocytes (polymorphonuclear leukocytes
(PMNs)) to sites of infection. The G protein-coupled receptor (GPR) 43 recognizes …

Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …

Colorectal cancer (CRC) remains one of the most common malignancies in the world.
Although surgical resection combined with adjuvant therapy is effective at the early stages of …