The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

The variety of shapes and sizes of the microtubule cytoskeleton is as great as the number of
different cell types. This large variety is a consequence of the dynamic properties of …

Tubulin undergoes posttranslational modifications proposed to specify microtubule
subpopulations for particular functions. Most of these modifications occur on the C-termini of …

The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from
providing tracks for intracellular transport, to supporting movement of cilia and flagella, to …

The human genome has three unique genes coding for kinesin-13 proteins called Kif2a,
Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis, but the …

Cells are the elementary units of living organisms, which are able to carry out many vital
functions. These functions rely on active processes on a microscopic scale. Therefore, they …

In mitosis, kinetochores are initially captured by the lateral sides of single microtubules and
are subsequently transported toward spindle poles. Mechanisms for kinetochore transport …

Plant cells have evolved cortical microtubules, in a two-dimensional space beneath the
plasma membrane [1, 2], that regulate patterning of cellulose deposition [3]. Although recent …

The separation of sister chromatids during anaphase is the culmination of mitosis and one of
the most strikingly beautiful examples of cellular movement. It consists of two distinct …

The integration of biophysical data from multiple sources is critical for developing accurate
structural models of large multiprotein systems and their regulators. Mass spectrometry (MS) …