The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines

G McLean, J Kamil, B Lee, P Moore, TF Schulz, A Muik… - MBio, 2022 - Am Soc Microbiol
The emergence of several new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in recent months has raised concerns around the potential impact on …

Emerging evidence on heterologous COVID-19 vaccine schedules—To mix or not to mix?

EPK Parker, S Desai, M Marti, KL O'Brien… - The Lancet Infectious …, 2022 - thelancet.com
As of February 2022, 27 different COVID-19 vaccines have been authorised by one or more
regulatory authorities for specific or widespread use. 1 Of these, eight vaccines have …

[HTML][HTML] SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses

AC Walls, KR Sprouse, JE Bowen, A Joshi, N Franko… - Cell, 2022 - cell.com
Although infections among vaccinated individuals lead to milder COVID-19 symptoms
relative to those in unvaccinated subjects, the specificity and durability of antibody …

Neutralizing activities against the Omicron variant after a heterologous booster in healthy adults receiving two doses of CoronaVac vaccination

S Assawakosri, S Kanokudom… - The Journal of …, 2022 - academic.oup.com
Background The use of an inactivated severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) vaccine (CoronaVac) against SARS-CoV-2 is implemented worldwide …

[HTML][HTML] Differential immunogenicity of homologous versus heterologous boost in Ad26. COV2. S vaccine recipients

NKH Khoo, JME Lim, US Gill, R de Alwis, N Tan… - Med, 2022 - cell.com
Background Protection offered by coronavirus disease 2019 (COVID-19) vaccines wanes
over time, requiring an evaluation of different boosting strategies to revert such a trend and …

Post-vaccination T cell immunity to omicron

H Jacobsen, V Cobos Jiménez, I Sitaras… - Frontiers in …, 2022 - frontiersin.org
In late 2021, the omicron variant of SARS Coronavirus 2 (SARS-CoV-2) emerged and
replaced the previously dominant delta strain. Effectiveness of COVID-19 vaccines against …

Booster COVID-19 vaccination against the SARS-CoV-2 Omicron variant: A systematic review

Y Du, L Chen, Y Shi - Human Vaccines & Immunotherapeutics, 2022 - Taylor & Francis
There is a wealth of data suggesting that the effectiveness of existing vaccines against the
Omicron variant, the most mutated SARS-CoV-2 variant to date, has been substantially …

BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA. 1 in …

A Seidel, M Zanoni, R Groß, D Krnavek… - Frontiers in …, 2022 - frontiersin.org
In light of the decreasing immune protection against symptomatic SARS-CoV-2 infection
after initial vaccinations and the now dominant immune-evasive Omicron variants,'booster' …

Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant

I Sitaras, H Jacobsen, MM Higdon, WE Dowling… - npj Vaccines, 2022 - nature.com
Virus neutralization data using post-vaccination sera are an important tool in informing
vaccine use policy decisions, however, they often pose interpretive challenges. We …

Retention of neutralizing response against SARS-CoV-2 omicron variant in sputnik V-Vaccinated individuals

D Lapa, DM Grousova, G Matusali, S Meschi… - Vaccines, 2022 - mdpi.com
The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly
spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2 …