Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to
mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying …

Background: The endogenous ecto-enzyme and exogenously administered alkaline
phosphatase (ALP) have been evidenced to significantly attenuate inflammatory conditions …

Simple Summary The lens organ of the eye and muscle tissue exist at opposite ends of the
metabolic spectrum. Lens is metabolically quiescent using little energy, while muscle has …

Tissue nonspecific alkaline phosphatase (TNAP/Alpl) is associated with cell stemness;
however, the function of TNAP in mesenchymal progenitor cells remains largely unknown. In …

Introduction Canis lupus familiaris is a domestic dog and many owners consider their pets
as a family member. Medical bills with dogs are overcame only by the health care received …

Aims PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We
previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 …

Heart failure (HF) is accompanied by complex alterations in myocardial energy metabolism.
Up to 40% of HF patients have dyssynchronous ventricular contraction, which is an …

Acute myocardial ischemia (AMI) remains the leading cause of death worldwide, and the
post-mortem diagnosis of AMI represents a current challenge for both clinical and forensic …

Metabolomics is an advanced technology, still under development, with multiple research
applications, especially in the field of health. Individual metabolic profiles, the functionality of …

Aims: Identifying patients who may benefit from mechanical circulatory support (MCS) after
out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC) remains …