Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Celastrol: a review of useful strategies overcoming its limitation in anticancer application

J Shi, J Li, Z Xu, L Chen, R Luo, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Advances in phytochemical delivery systems for improved anticancer activity

R Lagoa, J Silva, JR Rodrigues, A Bishayee - Biotechnology advances, 2020 - Elsevier
Natural compounds have significant anticancer pharmacological activities, but often suffer
from low bioavailability and selectivity that limit therapeutic use. The present work critically …

Exosome-based delivery of natural products in cancer therapy

H Song, B Liu, B Dong, J Xu, H Zhou, S Na… - Frontiers in cell and …, 2021 - frontiersin.org
A rapidly growing research evidence has begun to shed light on the potential application of
exosome, which modulates intercellular communications. As donor cell released vesicles …

Molecular targets of celastrol in cancer: Recent trends and advancements

D Kashyap, A Sharma, HS Tuli, K Sak… - Critical Reviews in …, 2018 - Elsevier
Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …

Nano-enabled plant-based colloidal delivery systems for bioactive agents in foods: Design, formulation, and application

MA Sani, M Tavassoli, M Azizi-Lalabadi… - Advances in Colloid and …, 2022 - Elsevier
Consumers are becoming increasingly aware of the impact of their dietary choices on the
environment, animal welfare, and health, which is causing many of them to adopt more plant …

Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype

SS Soni, AM D'Elia, A Alsasa, S Cho, T Tylek… - Biomaterials …, 2022 - pubs.rsc.org
Injectable hydrogels may be pre-formed through dynamic crosslinks, allowing for injection
and subsequent retention in the tissue by shear-thinning and self-healing processes …

Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review

O Abdifetah, K Na-Bangchang - International journal of …, 2019 - Taylor & Francis
The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical
effectiveness. The application of nanoparticles as a novel drug delivery system has provided …

[HTML][HTML] Nanovesicles-mediated drug delivery for oral bioavailability enhancement

Y Ren, L Nie, S Zhu, X Zhang - International Journal of …, 2022 - ncbi.nlm.nih.gov
Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery.
Adequate blood drug exposure after oral administration is a prerequisite for effective …