Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Abstract LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …

Pathogen‐associated molecular pattern molecules (PAMP s) are derived from
microorganisms and recognized by pattern recognition receptor (PRR)‐bearing cells of the …

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in
macrophages but its role in atherosclerosis is still poorly understood. Global deletion of …

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …