Diabetes, metabolic disease, and telomere length

F Cheng, L Carroll, MV Joglekar… - The Lancet Diabetes & …, 2021 - thelancet.com
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

[HTML][HTML] Telomere length and all-cause mortality: a meta-analysis

Q Wang, Y Zhan, NL Pedersen, F Fang, S Hägg - Ageing research reviews, 2018 - Elsevier
Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank

V Codd, M Denniff, C Swinfield, SC Warner… - Nature aging, 2022 - nature.com
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …

Identification of seven loci affecting mean telomere length and their association with disease

V Codd, CP Nelson, E Albrecht, M Mangino, J Deelen… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Ageing and the telomere connection: An intimate relationship with inflammation

J Zhang, G Rane, X Dai, MK Shanmugam… - Ageing research …, 2016 - Elsevier
Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?

JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

A systematic review of leukocyte telomere length and age in adults

A Müezzinler, AK Zaineddin, H Brenner - Ageing research reviews, 2013 - Elsevier
OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …

A quantitative PCR method for measuring absolute telomere length

NJ O'Callaghan, M Fenech - Biological procedures online, 2011 - Springer
We describe a simple and reproducible method to measure absolute telomere length (aTL)
using quantitative real-time polymerase chain reaction (qPCR). This method is based on the …

Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study

M Crous-Bou, TT Fung, J Prescott, B Julin, M Du, Q Sun… - Bmj, 2014 - bmj.com
Objective To examine whether adherence to the Mediterranean diet was associated with
longer telomere length, a biomarker of aging. Design Population based cohort study. Setting …

Gender and telomere length: systematic review and meta-analysis

M Gardner, D Bann, L Wiley, R Cooper, R Hardy… - Experimental …, 2014 - Elsevier
Background It is widely believed that females have longer telomeres than males, although
results from studies have been contradictory. Methods We carried out a systematic review …