Bone grafts are the second most common tissue transplanted in the United States, and they
are an essential treatment tool in the field of acute and reconstructive traumatic orthopaedic …

Bone replacement might have been practiced for centuries with various materials of natural
origin, but had rarely met success until the late 19th century. Nowadays, many different bone …

Background context Increasingly, reports of frequent and occasionally catastrophic
complications associated with use of recombinant human bone morphogenetic protein-2 …

Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial
biomaterial and approved medical device used in bone defects with a long track record of …

Orthopaedic trauma surgery requires the regular use of bone grafts to help provide timely
healing of musculoskeletal injuries. The iliac crest autologous graft remains the gold …

Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially
in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest …

We reviewed 59 bone graft substitutes marketed by 17 companies currently available for
implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to …

Spinal arthrodesis is an essential procedure in spine surgery which is performed to fuse two
or more vertebrae. Success rates and outcomes strictly depend on substrates used to …

Musculoskeletal defects are an enormous healthcare burden and source of pain and
disability for individuals. With an aging population, the proportion of individuals living with …

Objective The fusion rate in spinal surgery may vary in relation to the technique, and it
remains unknown which surgical technique provides the best fusion rate and surgical …