Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

Mycobacterium tuberculosis is the cause of one of the most important infectious diseases in
humans, which leads to 1.4 million deaths every year. Specialized protein transport systems …

Mycobacteria use type VII secretion (T7S) systems to secrete proteins across their complex
cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium …

The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the
ess locus. T7 substrate recognition and protein transport are mediated by EssC, a …

Host infection by pathogenic mycobacteria, such as Mycobacterium tuberculosis, is
facilitated by virulence factors that are secreted by type VII secretion systems. A molecular …

The ESX (or Type VII) secretion systems are protein export systems in mycobacteria and
many Gram-positive bacteria that mediate a broad range of functions including virulence …

Bacterial secretion systems were initially studied in the Gram‐negative bacterium
Escherichia coli K‐12. When researchers started to explore protein secretion in different …

Mycobacterium tuberculosis (Mtb) uses the ESX-1 type VII secretion system to export
virulence proteins across its lipid-rich cell wall, which helps permeabilize the host's …

Bacteria have many export and secretion systems that translocate cargo into and across
biological membranes. Seven secretion systems contribute to pathogenicity by translocating …