Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

The amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer's
disease (AD), leading to many small-molecule and biological drug candidates. One major …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Based on the tremendous pharmacological activities of compounds containing thiazole and
carboxamide moieties, the current study aims to prepare new series of thiazole, pyrazole …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and
irreversible impairment of memory and other cognitive functions of the aging brain …

A further refinement to our previously published “target-bound pharmacophore modeling
approach” is reported herein. Instead of relying on “random” pharmacophores—which is the …

The human tyrosinase is the most prominent therapeutic target for pigmentary skin
disorders. However, the overwhelming majority efforts have been devoted to search …

Abstract Novel series of fused 1, 4‐dihydropyridine derivatives were designed and
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …

Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …

A novel series of N‐(2‐(piperazin‐1‐yl) phenyl) aryl carboxamide derivatives were simply
synthesized by Ugi‐multicomponent reaction as β‐secretase (BACE1) inhibitors. The …