Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Significance: Amyotrophic lateral sclerosis (ALS) is due to degeneration of upper and lower
motor neurons in the anterior horn of the spinal cord and in the motor cortex. Mechanisms …

Protein aggregation is a biological process that occurs when proteins misfold. Misfolding
and aggregation of human superoxide dismutase (hSOD1) cause a neurodegenerative …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has been
associated with mutations in metalloenzyme superoxide dismutase (SOD1) causing protein …

By virtue of their regulatory role in the biological process, certain protein–protein complexes
form potential targets for designing and discovery of drugs. Alteration set in the controlled …

Protein aggregation is a hallmark of various neurodegenerative disorders, such as
amyotrophic lateral sclerosis (ALS) in humans. Mutations in Cu/Zn superoxide dismutase …

The major candidate for multiple sulfatase deficiency is a defective formylglycine-generating
enzyme (FGE). Though adequately produced, mutations in FGE stall the activation of …

Mutations in the gene encoding Cu/Zn Superoxide Dismutase 1 (SOD1) protein are
contemplated to be a protruding reason for Amyotrophic lateral sclerosis (ALS), which leads …

In the present study, we aimed to formulate an effective therapeutic candidate against V30M
mutant transthyretin (TTR) protein to hinder its pathogenic misfolding. Nicotiana alata …