Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …

Although long noncoding RNAs (lncRNAs) dominate the transcriptome, their functions are
largely unexplored. The extensive overlap of lncRNAs with coding and regulatory …

Abstract Background/Objectives: Early and aggressive metastasis is a major feature of
pancreatic ductal adenocarcinoma. Understanding the processes underlying metastasis is …

CRISPR screen technology enables systematic and scalable interrogation of gene function
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …

Simple Summary Clustered regularly interspaced short palindromic repeats (CRISPR) were
discovered in prokaryotes, and the technology can also be used to edit the genome in …

CRISPR-based genetic screening directly in mammalian tissues in vivo is challenging due
to the need for scalable, cell-type selective delivery and recovery of guide RNA libraries. We …

Genetic interactions (GIs) refer to two altered genes having a combined effect that is not
seen individually. They play a crucial role in influencing drug efficacy. We utilized CGIdb 2.0 …

In contrast to mono-or biallelic loss of tumor-suppressor function, effects of discrete gene
dysregulations, as caused by non-coding (epi) genome alterations, are poorly understood …

A decade ago, the hallmark paper by Platt et al. was published on the in vivo application of
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to generate cancer in …