Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Summary DNA N 6-methyladenine (6mA) modification is the most prevalent DNA
modification in prokaryotes, but whether it exists in human cells and whether it plays a role in …

Abstract N 1-Methyladenosine (m1A) is a prevalent post-transcriptional RNA modification,
yet little is known about its abundance, topology and dynamics in mRNA. Here, we show that …

Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Summary tRNA is a central component of protein synthesis and the cell signaling network.
One salient feature of tRNA is its heavily modified status, which can critically impact its …

The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …

The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate-and Fe
(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein …