Multiple faces of anxiety: a frontal lobe perspective
AC Roberts, KG Mulvihill - Trends in Neurosciences, 2024 - cell.com
Marked dysregulation of the human prefrontal cortex (PFC) and anterior cingulate cortex
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …
Noncortical cognition: integration of information for close-proximity behavioral problem-solving
L Pessoa - Current Opinion in Behavioral Sciences, 2024 - Elsevier
Highlights•Behavioral problems conceptualized in terms of gradient of spatiotemporal
proximity.•Solving close-proximity behavioral problems involves integrating disparate …
proximity.•Solving close-proximity behavioral problems involves integrating disparate …
The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat
Avoidance, a hallmark of anxiety-related psychopathology, often comes at a cost; avoiding
threat may forgo the possibility of a reward. Theories predict that optimal approach …
threat may forgo the possibility of a reward. Theories predict that optimal approach …
Dynamic threat–reward neural processing under semi‐naturalistic ecologically relevant scenarios
DJ Levitas, TW James - Human Brain Mapping, 2024 - Wiley Online Library
Studies of affective neuroscience have typically employed highly controlled, static
experimental paradigms to investigate the neural underpinnings of threat and reward …
experimental paradigms to investigate the neural underpinnings of threat and reward …
The neurobiology of aesthetic chills: How bodily sensations shape emotional experiences
The phenomenon of aesthetic chills—shivers and goosebumps associated with either
rewarding or threatening stimuli—offers a unique window into the brain basis of conscious …
rewarding or threatening stimuli—offers a unique window into the brain basis of conscious …
How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach–Avoidance Decisions
Healthy and successful living involves carefully navigating rewarding and threatening
situations by balancing approach and avoidance behaviors. Excessive avoidance to evade …
situations by balancing approach and avoidance behaviors. Excessive avoidance to evade …
Persistent threat avoidance following negative reinforcement is not associated with elevated state anxiety
EA Crummy, BL Chamberlain, JP Gamboa… - Journal of …, 2025 - jneurosci.org
Obsessive-compulsive disorder (OCD) is a debilitating illness consisting of obsessions and
compulsions. OCD severity and treatment response are correlated with avoidant behaviors …
compulsions. OCD severity and treatment response are correlated with avoidant behaviors …
Rethinking category-selectivity in human visual cortex
A wealth of studies report evidence that occipitotemporal cortex tessellates into" category-
selective" brain regions that are apparently specialized for representing ecologically …
selective" brain regions that are apparently specialized for representing ecologically …
[HTML][HTML] Brain dynamics and spatiotemporal trajectories during threat processing
J Misra, L Pessoa - eLife, 2025 - elifesciences.org
In the past decades, functional MRI research has investigated task processing in largely
static fashion based on evoked responses during blocked and event-related designs …
static fashion based on evoked responses during blocked and event-related designs …
Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental …
Background: Reward and threat processes work together to support adaptive learning
during development. Adolescence is associated with increasing approach behavior (eg …
during development. Adolescence is associated with increasing approach behavior (eg …