Multiple myeloma (MM) is an acquired malignant plasma cell disorder that develops late in
life. Although progression free and overall survival has improved across all age, race, and …

Polyploidy is typically described as the condition wherein a cell or organism has more than
two complete sets of chromosomes. Occurrence of polyploidy is a naturally occurring …

Simple Summary Myeloma is a hematological cancer characterized by numerous genetic
abnormalities currently identified using fluorescent in situ hybridization (FISH). However …

Hyperdiploidy (HRD) and specific immunoglobulin heavy locus (IGH) translocations are
primary chromosomal abnormalities (CA) in multiple myeloma (MM). In this retrospective …

Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is
known that MM tumor cells display extensive intratumoral genetic heterogeneity, an …

Fluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect
recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since …

Multiple myeloma is a plasma cell neoplasm driven by primary (eg hyperdiploidy; IGH
translocations) and secondary (eg 1q21 gains/amplifications; del (17p); MYC translocations) …

Multiple myeloma (MM) is a heterogeneous disease featured by clonal plasma cell
proliferation and genomic instability. The advent of next-generation sequencing allowed …

Multiple myeloma (MM) is a heterogeneous group of mature B‐cell diseases that are
typically characterized by the presence and accumulation of abnormal plasma cells (PCs) …

Whole-genome duplication (WGD) generates polyploid cells possessing more than two
copies of the genome and is among the most common genetic abnormalities in cancer. The …