Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …
The release and trans-synaptic transmission of Tau via exosomes
Y Wang, V Balaji, S Kaniyappan, L Krüger… - Molecular …, 2017 - Springer
Background Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears
in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding …
in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding …
Clearance systems in the brain—implications for Alzheimer disease
Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …
Tau and neurodegenerative disease: the story so far
In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …
In the previous year, a paired helical filament (PHF) protein had been identified in …