Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …

Elucidating physiological and pathogenic functions of protein methyltransferases (PMTs)
relies on knowing their substrate profiles. S-adenosyl-l-methionine (SAM) is the sole methyl …

Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …

Using enrichment strategies many research groups are routinely producing large data sets
of post-translationally modified peptides for proteomic analysis using tandem mass …

Protein methyltransferases (PMTs) play critical roles in multiple biological processes.
Because PMTs often function in vivo through forming multimeric protein complexes …

Protein lysine methyltransferases (PKMTs) play crucial roles in normal physiology and
disease processes. Profiling PKMT targets is an important but challenging task. With cancer …

Protein methylation is the smallest possible yet vitally important post-translational
modification (PTM). This small and chemically inert addition in proteins makes the analysis …

Posttranslational histone modifications define chromatin structure and function. In recent
years, a number of studies have characterized many of the enzymatic activities and diverse …

Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-
translational modification regulating many signaling pathways. It has direct and indirect …