Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

We present recent progress in understanding the anomalous behavior of water ice under
mechanical compression, thermal excitation, and molecular undercoordination (with fewer …

The ice-water interface is commonly encountered in our life, and comes into play in a wide
number of natural phenomena. Here, attention will be focused on its effects on protein …

Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Therapeutic proteins are exposed to numerous stresses during their manufacture, shipping,
storage and administration to patients, causing them to aggregate and form particles through …

Biological liquid crystals, a rich set of soft materials with rod‐like structures widely existing in
nature, possess typical lyotropic liquid crystalline phase properties both in vitro (eg …

Innovations in cryogenic electron microscopy (Cryo-EM) have led to high-quality structures
of important proteins such as the ribosome and γ-secretase, the membrane protease that …

Lyophilization of proteins can introduce lot-to-lot variabilities in different product properties
that are crucial in terms of product performance and stability. As these variations can raise …

Protein/ice interactions are investigated by a novel method based on measuring the
characteristic features of X-ray diffraction (XRD) patterns of hexagonal ice (Ih). Aqueous …

We studied the effects of pH and solution additives on freezing-induced perturbations in the
tertiary structure of a monoclonal antibody (mAb) by intrinsic tryptophan fluorescence …