Small-molecule drug discovery in triple negative breast cancer: current situation and future directions
M Liao, J Zhang, G Wang, L Wang, J Liu… - Journal of medicinal …, 2021 - ACS Publications
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …
an effective targeted therapy has not been well-established so far. Considering the lack of …
Cardiac repolarization in health and disease
C Krijger Juárez, AS Amin, JA Offerhaus… - Clinical …, 2023 - jacc.org
Abnormal cardiac repolarization is at the basis of life-threatening arrhythmias in various
congenital and acquired cardiac diseases. Dysfunction of ion channels involved in …
congenital and acquired cardiac diseases. Dysfunction of ion channels involved in …
COVID-19 drugs chloroquine and hydroxychloroquine, but not azithromycin and remdesivir, block hERG potassium channels
M Szendrey, J Guo, W Li, T Yang, S Zhang - Biophysical Journal, 2021 - cell.com
Drug-induced long QT syndrome (LQTS) is an established cardiac side effect of a wide
range of medications, which represents a significant concern for drug safety. The common …
range of medications, which represents a significant concern for drug safety. The common …
[HTML][HTML] hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction
A El Harchi, JC Hancox - Journal of Pharmacological and Toxicological …, 2023 - Elsevier
Pharmacological blockade of the I Kr channel (hERG) by diverse drugs in clinical use is
associated with the Long QT Syndrome that can lead to life threatening arrhythmia. Various …
associated with the Long QT Syndrome that can lead to life threatening arrhythmia. Various …
Short QT syndrome
C Antzelevitch - Management of Cardiac Arrhythmias, 2020 - Springer
Short QT syndrome (SQTS) is an inherited channelopathy responsible for sudden cardiac
death (SCD) in individuals with a structurally normal heart. It is characterized by abnormally …
death (SCD) in individuals with a structurally normal heart. It is characterized by abnormally …
Effects of COVID-19 drugs chloroquine, hydroxychloroquine, azithromycin and remdesivir on hERG expression and function
MG Szendrey - 2021 - search.proquest.com
A prolongation of the cardiac action potential may present itself as long QT syndrome
(LQTS). LQTS can occur as a side effect of a wide variety of medications. A common cause …
(LQTS). LQTS can occur as a side effect of a wide variety of medications. A common cause …