Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary …

PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …

We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …

OBJECTIVE Previous studies have reported that β-cell mitochondria exist as discrete
organelles that exhibit heterogeneous bioenergetic capacity. To date, networking activity …

The aetiology of type 2, or non-insulin-dependent, diabetes mellitus has been characterized
in only a limited number of cases. Among these, mitochondrial diabetes, a rare subform of …

Widely varied chemicals—including certain herbicides, plasticizers, drugs, and natural
products—induce peroxisome proliferation in rodent liver and other tissues. This …