Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote

G Schönknecht, WH Chen, CM Ternes, GG Barbier… - Science, 2013 - science.org
Some microbial eukaryotes, such as the extremophilic red alga Galdieria sulphuraria, live in
hot, toxic metal-rich, acidic environments. To elucidate the underlying molecular …

Computational design of stable and soluble biocatalysts

M Musil, H Konegger, J Hon, D Bednar… - Acs Catalysis, 2018 - ACS Publications
Natural enzymes are delicate biomolecules possessing only marginal thermodynamic
stability. Poorly stable, misfolded, and aggregated proteins lead to huge economic losses in …

[图书][B] Computational phylogenetics: an introduction to designing methods for phylogeny estimation

T Warnow - 2018 - books.google.com
A comprehensive account of both basic and advanced material in phylogeny estimation,
focusing on computational and statistical issues. No background in biology or computer …

Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution

DR Nelson, KM Hazzouri, KJ Lauersen, A Jaiswal… - Cell host & …, 2021 - cell.com
Being integral primary producers in diverse ecosystems, microalgal genomes could be
mined for ecological insights, but representative genome sequences are lacking for many …

Crystal structure of a membrane-bound O-acyltransferase

D Ma, Z Wang, CN Merrikh, KS Lang, P Lu, X Li… - Nature, 2018 - nature.com
Membrane-bound O-acyltransferases (MBOATs) are a superfamily of integral
transmembrane enzymes that are found in all kingdoms of life. In bacteria, MBOATs modify …

Know your enemy: successful bioinformatic approaches to predict functional RNA structures in viral RNAs

CS Lim, CM Brown - Frontiers in microbiology, 2018 - frontiersin.org
Structured RNA elements may control virus replication, transcription and translation, and
their distinct features are being exploited by novel antiviral strategies. Viral RNA elements …

Selection on noise constrains variation in a eukaryotic promoter

BPH Metzger, DC Yuan, JD Gruber, F Duveau… - Nature, 2015 - nature.com
Genetic variation segregating within a species reflects the combined activities of mutation,
selection, and genetic drift. In the absence of selection, polymorphisms are expected to be a …

Selenzyme: enzyme selection tool for pathway design

P Carbonell, J Wong, N Swainston, E Takano… - …, 2018 - academic.oup.com
Synthetic biology applies the principles of engineering to biology in order to create
biological functionalities not seen before in nature. One of the most exciting applications of …

Molecular phylogeny of the genus Taenia (Cestoda: Taeniidae): proposals for the resurrection of Hydatigera Lamarck, 1816 and the creation of a new genus Versteria

M Nakao, A Lavikainen, T Iwaki, V Haukisalmi… - International Journal for …, 2013 - Elsevier
The cestode family Taeniidae generally consists of two valid genera, Taenia and
Echinococcus. The genus Echinococcus is monophyletic due to a remarkable similarity in …

Mitochondrial phylogeny of the genus Echinococcus (Cestoda: Taeniidae) with emphasis on relationships among Echinococcus canadensis genotypes

M Nakao, T Yanagida, S Konyaev, A Lavikainen… - Parasitology, 2013 - cambridge.org
The mitochondrial genomes of the genus Echinococcus have already been sequenced for
most species and genotypes to reconstruct their phylogeny. However, two important taxa, E …