Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum,
which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance …

Gastric ulcer is the damage caused to mucosal layer of the stomach under the action of
various factors like high levels of acid and pepsin, invasion by Helicobacter pylori, etc …

Click chemistry was used to synthesize a new series of thioquinazolinone molecules
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …

Mangroves are unique coastal forest ecosystem distributed along the tropical and
subtropical region of the world. They are evolutionarily adapted to combat against hostile …

Abstract New pyrazolo [3, 4-d] pyrimidines substituted with various functionalities or attached
to a substituted pyrazole ring through different linkages were synthesized. The synthesized …

As a new approach to the management of inflammatory disorders, a series of chromone-
based derivatives containing a (carbamate) hydrazone moiety was designed and …

Abstract New thymol− 1, 5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-
LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against …

Colorectal cancer (CRC) is the second cause of cancer death worldwide. Inhibitors of COX-
2, 5-LOX and PIM-1 kinase were very effective in the treatment and prevention of CRC in …

Abstract New pyrazolo [3, 4-d] pyrimidinone and pyrazolo [4, 3-e][1, 2, 4] triazolo [4, 3-a]
pyrimidinone derivatives were synthesized. They have been evaluated for their anti …

Two new series of pyrazolo [3, 4-d] pyrimidine bearing thiazolidinone moiety were designed
and synthesized. The newly synthesized compounds were evaluated for their in vitro (COX-1 …