[HTML][HTML] Anti-diabetics and antimicrobials: Harmony of mutual interplay
WAH Hegazy, AAH Rajab, ASA Lila… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Diabetes is one of the four major non-communicable diseases, and appointed by the world
health organization as the seventh leading cause of death worldwide. The scientists have …
health organization as the seventh leading cause of death worldwide. The scientists have …
A role for SGLT-2 inhibitors in treating non-diabetic chronic kidney disease
L Del Vecchio, A Beretta, C Jovane, S Peiti, S Genovesi - Drugs, 2021 - Springer
In recent years, inhibitors of the sodium-glucose co-transporter 2 (SGLT2 inhibitors) have
been shown to have significant protective effects on the kidney and the cardiovascular …
been shown to have significant protective effects on the kidney and the cardiovascular …
Sodium-glucose transport protein 2 inhibitor use for type 2 diabetes and the incidence of acute kidney injury in Taiwan
MC Chung, PH Hung, PJ Hsiao, LY Wu… - JAMA Network …, 2023 - jamanetwork.com
Importance The association between sodium-glucose transport protein 2 inhibitor (SGLT2i)
use and the incidence of acute kidney injury (AKI) remains controversial. The benefits of …
use and the incidence of acute kidney injury (AKI) remains controversial. The benefits of …
Dapagliflozin alleviates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation in unilateral ureteral obstruction
MY Xuan, SG Piao, J Ding, QY Nan, MH Piao… - Frontiers in …, 2022 - frontiersin.org
Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes.
However, potential for use in nondiabetic kidney disease remains unknown. Herein, we …
However, potential for use in nondiabetic kidney disease remains unknown. Herein, we …
Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling …
RM Salama, RH Ahmed, AA Farid… - International …, 2023 - Elsevier
Alcohol abuse may lead to the development of gastric mucosal lesions. Dapagliflozin
(DAPA), a sodium-glucose cotransporter-2 inhibitor, is clinically used to treat type 2 diabetes …
(DAPA), a sodium-glucose cotransporter-2 inhibitor, is clinically used to treat type 2 diabetes …
Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR-21 and-155 expression, Nrf2/HO-1 and p38-MAPK/NF-κB pathways
Gentamicin (GNT) is the most frequently used aminoglycoside. However, its therapeutic
efficacy is limited due to nephrotoxicity. Thus, the potential anticipatory effect of Diosmin …
efficacy is limited due to nephrotoxicity. Thus, the potential anticipatory effect of Diosmin …
Stimulation of autophagy by dapagliflozin mitigates cadmium-induced testicular dysfunction in rats: the role of AMPK/mTOR and SIRT1/Nrf2/HO-1 pathways
Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction.
Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable …
Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable …
Investigation into the effect and mechanism of dapagliflozin against renal interstitial fibrosis based on transcriptome and network pharmacology
Y Liu, Y Wang, S Chen, L Bai, X Xie, L Zhang… - International …, 2022 - Elsevier
Background Renal interstitial fibrosis (RIF) is the final pathway for chronic kidney diseases
(CKD) to end-stage renal disease (ESRD). Dapagliflozin, a selective inhibitor of the sodium …
(CKD) to end-stage renal disease (ESRD). Dapagliflozin, a selective inhibitor of the sodium …
Dapagliflozin improves early acute kidney injury induced by vancomycin in rats: Insights on activin A/miRNA-21 signaling and FOXO3a expression
Drug-induced acute kidney injury (AKI) represents a potentially serious disorder associated
with increased morbidity and mortality. The presented study investigated the ability of the …
with increased morbidity and mortality. The presented study investigated the ability of the …
Curcumin mitigates neurotoxic and neurobehavioral changes of gentamicin and sodium salicylate in rats by adjusting oxidative stress and apoptosis
YM Abd-Elhakim, SM Abdel-Motal, SM Malhat… - Life Sciences, 2021 - Elsevier
Currently, antibiotics and salicylates are the most highly consumed medications worldwide.
The side effects of these pharmaceuticals on the nervous system have been little …
The side effects of these pharmaceuticals on the nervous system have been little …