Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …

Medulloblastoma (MB) is the most common malignant brain tumor in children and among
the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient …

Malignant brain tumors are highly heterogeneous tumors with a poor prognosis and a high
morbidity and mortality rate in both children and adults. The cancer stem cell (CSC, also …

Brain tumors are highly heterogeneous and have been classified by the World Health
Organization in various histological and molecular subtypes. Gliomas have been classified …

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is
amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 …

Background Medulloblastoma is the most common malignant pediatric brain tumor and
group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers …

OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma.
However, the mechanisms by which OTX2 represses neural differentiation are not well …

OTX homeobox genes have been extensively studied for their role in development,
especially in neuroectoderm formation. Recently, their expression has also been reported in …

CHD7 is a chromatin remodeler protein that controls gene expression via the formation of
multi-protein complexes with specific transcription factors. During development, CHD7 …

Lung adenocarcinoma (LUAD) was the predominant histological subtype of lung cancer,
with poor prognosis. By analyzing the TCGA dataset, we found that DMBX1 (diencephalon …