Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Publisher Summary This chapter discusses the lymphocyte trafficking and regional
immunity. The chapter discusses the present understanding of tissue-selective lymphocyte …

Bone-marrow minimal residual disease (MRD) causes relapse after chemotherapy in
patients with acute myelogenous leukemia (AML). We postulate that the drug resistance is …

We generated vascular cell adhesion molecule (VCAM)-1 “knock-in” mice and Cre
recombinase transgenic mice to delete the VCAM-1 gene (vcam-1) in whole mice, thereby …

This review focuses on providing insights into the structural basis and clinical relevance of
LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based …

Introduction 3. Discussion 3.1. Fibronectin 3.2. Integrins 3.3. Molecular mechanisms of
ligand-integrin interactions 3.4. Ligand specificity of fibronectin binding integrins 3.5 …

Considerable advances have been made in our knowledge of the molecular structure of cell
adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein …

The N-terminal≈ 440 aa of integrin α subunits contain seven sequence repeats. These are
predicted here to fold into a β-propeller domain. A homologous domain from the enzyme …

Small peptide–based agents have attracted wide interest as cancer-targeting agents for
diagnostic imaging and targeted therapy. There is a need to develop new high-affinity and …

Once specified to become neural crest (NC), cells occupying the dorsal portion of the neural
tube disrupt their cadherin-mediated cell-cell contacts, acquire motile properties, and …