Enhancing cell therapies from the outside in: cell surface engineering using synthetic nanomaterials
MT Stephan, DJ Irvine - Nano today, 2011 - Elsevier
Therapeutic treatments based on the injection of living cells are in clinical use and
preclinical development for diseases ranging from cancer to cardiovascular disease to …
preclinical development for diseases ranging from cancer to cardiovascular disease to …
[HTML][HTML] Converting extracellular vesicles into nanomedicine: loading and unloading of cargo
Extracellular vesicles (EVs) are membranous containers that are secreted by multiple cell
types and actively transport biomolecules such as lipids, proteins, and nucleic acids to …
types and actively transport biomolecules such as lipids, proteins, and nucleic acids to …
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for
maintenance immunosuppression. We report a strategy through which cotransplantation of …
maintenance immunosuppression. We report a strategy through which cotransplantation of …
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic
immunosuppression to control rejection of allogeneic islets induces morbidities and impairs …
immunosuppression to control rejection of allogeneic islets induces morbidities and impairs …
Rapid on-demand extracellular vesicle augmentation with versatile oligonucleotide tethers
Exosomes show potential as ideal vehicles for drug delivery because of their natural role in
transferring biological cargo between cells. However, current methods to engineer …
transferring biological cargo between cells. However, current methods to engineer …
[HTML][HTML] Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond
S Abbaszadeh, V Nosrati-Siahmazgi, K Musaie… - Advanced Drug Delivery …, 2023 - Elsevier
Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …
of impaired tissues or organs. While current technologies can enhance the survival of …
Layer-by-layer assembly of a conformal nanothin PEG coating for intraportal islet transplantation
JT Wilson, W Cui, EL Chaikof - Nano letters, 2008 - ACS Publications
Encapsulation of cells and tissue offers a rational approach for attenuating deleterious host
responses toward transplanted cells, but a need exists to develop cell encapsulation …
responses toward transplanted cells, but a need exists to develop cell encapsulation …
Challenges and emerging technologies in the immunoisolation of cells and tissues
JT Wilson, EL Chaikof - Advanced drug delivery reviews, 2008 - Elsevier
Protection of transplanted cells from the host immune system using immunoisolation
technology will be important in realizing the full potential of cell-based therapeutics …
technology will be important in realizing the full potential of cell-based therapeutics …
Local Immunomodulatory Strategies to Prevent Allo‐Rejection in Transplantation of Insulin‐Producing Cells
Islet transplantation has shown promise as a curative therapy for type 1 diabetes (T1D).
However, the side effects of systemic immunosuppression and limited long‐term viability of …
However, the side effects of systemic immunosuppression and limited long‐term viability of …
Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival
Antibody-mediated immune checkpoint blockade is a transformative immunotherapy for
cancer. These same mechanisms can be repurposed for the control of destructive …
cancer. These same mechanisms can be repurposed for the control of destructive …