Histamine is a biogenic amine with extensive effects on many cell types, mediated by the
activation of its four receptors (H 1 R–H 4 R). Distinct effects are dependent on receptor …

Consensus group on new-generation antihistamines (CONGA): present status and
recommendations Page 1 Consensus group on new-generation antihistamines (CONGA) …

Background Cold contact urticaria (CCU) is characterized by itchy wheal and flare
responses due to the release of histamine and other pro‐inflammatory mediators after …

Background: Proinflammatory mediators such as the cysteinyl leukotrienes are important in
the pathophysiology of allergic rhinitis. This study evaluated the efficacy and tolerability of …

ABSTRACT Leukotriene B 4 (LTB 4) is a lipid mediator with potent chemoattractant
properties and that is rapidly generated from activated innate immune cells such as …

Controlled drug delivery is a valuable strategy for increasing local therapeutic
concentrations in a sustained manner, particularly in locations that are difficult to access …

Rupatadine is a new agent for the management of diseases with allergic inflammatory
conditions, such as seasonal and perennial rhinitis. The pharmacological profile of …

Allergic rhinitis is an inflammatory disorder of the nasal mucosa, mediated by TH2
lymphocytes, which is linked to atopy and whose prevalence is increasing in association …

Allergic rhinitis is the most common atopic disorder seen in ENT clinics. It is diagnosed by
history, physical exam and objective testing. Patient education, environmental control …

Objective: To conduct a systematic review of evidence supporting the safety profiles of
frequently used oral H1-antihistamines (AHs) for the treatment of patients with histamine …