Tumors are usually classified into two main categories–benign or malignant, with much
more attention being devoted to the second category given that they are usually associated …

The past thirty years have seen a surge in interest in pathophysiological roles of
mitochondria, and the accurate quantification of mitochondrial DNA copy number (mCN) in …

Abstract Changes in mitochondrial DNA (mtDNA) content is a useful clinical biomarker for
various diseases, however results are controversial as several analytical factors can affect …

Background Colorectal adenocarcinomas are characterized by abnormal mitochondrial
DNA (mtDNA) copy number and genomic instability, but a molecular interaction between …

Mitochondria are central key players in cell metabolism, and mitochondrial DNA (mtDNA)
instability has been linked to metabolic changes that contribute to tumorigenesis and to …

Background The identification of novel functional biomarkers is essential for recognizing
high-risk patients, predicting recurrence, and searching for appropriate treatment. However …

Mitochondria are organelles that perform major roles in cellular operation. Thus, alterations
in mitochondrial genome (mtGenome) may lead to mitochondrial dysfunction and cellular …

Background Energy metabolism in carcinogenesis is poorly understood. It is widely
accepted the majority of colorectal cancers (CRCs) arise from adenomatous polyps (APs) …

Apart from reliable management of the “powerhouse” of the cell, mitochondria faithfully
orchestrate a diverse array of important and critical functions in governing cellular signaling …

Growing evidence supports a general hypothesis that aging and cancer are diseases
related to energy metabolism. However, the involvement of Fanconi Anemia (FA) signaling …