Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures.
Approximately one-third of epilepsy patients will not achieve seizure freedom with medical …

Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it
all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating …

Dravet syndrome (DS) is a severe epilepsy syndrome that starts within the first year of life. In
a clinical study, add-on treatment with fenfluramine, a potent 5-hydroxytryptamine (5-HT) …

In this paper, we review the experience with fenfluramine in epileptic and other paroxysmal
disorders. Since the best available data are from the treatment of Dravet syndrome, we will …

A large body of experimental and clinical evidence has strongly suggested that monoamines
play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and …

Mesial temporal lobe epilepsy (MTLE) is a chronic neurological disorder characterized by
the occurrence of seizures, and histopathological abnormalities in the mesial temporal lobe …

Several lines of evidence link deficient serotonin function and SUDEP. Chronic treatment
with serotonin reuptake inhibitors (SRIs) reduces ictal central apnoea, a risk factor for …

Epilepsy is one of the most prevalent neurological disorder affecting more than 50 million
people worldwide. Numerous studies have suggested that an imbalance in glutamatergic …

Serotonin is implicated in the regulation of seizures, but whether or not it can potentiate the
effects of epileptogenic factors is not fully established. Using the kainic acid model of …

Studies in animal models of epilepsy revealed compromised serotonin (5-HT) transmission
between the raphe nuclei and the brain limbic system. The goal of the present study was to …